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. 2022 Jan 25;9:813249. doi: 10.3389/fnut.2022.813249

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Copyright © 2022 Xu, Li, Yao, Xie, Chi, Zhang, Cao and Tan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Further analyses of proteomic profiles of liver samples in CD, HD, and B3D groups. (A) the largest two weight-scores of principal components (PC) in the protein composition: PC1 explained 20.1% of the total variability of the data, and PC2 explained 14.1% (n = 3). (B) the amount of down or upregulated DEPs in the HD vs. CD, B3D vs. HD, and B3D vs. CD group comparisons. Proteins with a fold change larger than 1.5 and a P-value below 0.05 (using the Benjamini-Hochberg multiple testing correction test) were designated as DEPs. (C) The heatmap of DEPs in the HD group (compared to the CD group) and B3D group (compared to the HD group). (D) The heatmap of DEPs in the HD group (compared to the CD group). (E) the heatmap of DEPs in the B3D group (compared to the HD group). (F) the amount of down or upregulated DEPs in the KEGG enrichment analysis of HD vs. CD and B3D vs. HD group comparisons.