TABLE 1.

Emerging therapies targeting Th17 cell responses in corticosteroid-insensitive asthma

Target	Reagent	Type of drug	System	Reference
IL-17A	Anti-IL17A	mAb	Mice	183
	Secukinumab/CJM112	mAb	Human	184, 185
IL-17RA	Brodalumab	mAb	Human	186
IL-6	MP5-20F3	mAb	Mice	193
IL-6R	Atlizumab	mAb	Mice	166
	Tocilizumab	mAb	Human	201
	Clazakizumab	mAb	Human	202
IL-1β	Canakinumab	mAb	Human	214
IL-1R1	Anakinra	Antagonist	Human	210, 215
RORγt	TMP778/920	Inverse agonists	Cells	218–220
	Ursolic acid	Inhibitor	Mice	179
	VTP-938	Inverse agonist	Mice	225
	BIX119	Inhibitor	Mice	115
	JNJ-61803534	Inhibitor	Mice and human	226
RhoA	Y16	Inhibitor	Mice	232
ROCK2	KD025	Inhibitor	Mice	234