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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Metabolism. 2022 Jan 7;128:155117. doi: 10.1016/j.metabol.2021.155117

Figure 1: Schematic of study protocol performed in healthy humans.

Figure 1:

Each participant underwent two study visits during which either a 4-hour sham/saline infusion (Study Day 1, left) or a hyperinsulinemic clamp (Study Day 2, right) was performed, and then on both occasions arginine was administered to stimulate endogenous insulin secretion as both a 5g intravenous bolus (at time 240 minutes), and a 500 mg/kg continuous infusion (time 260–290 minutes).