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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Mol Aspects Med. 2021 Nov 28;84:101056. doi: 10.1016/j.mam.2021.101056

Figure 3.

Figure 3.

SNO(Cys93)-Hb induces hypoxic vasodilation and tissue oxygen delivery. A. RBCs derived from C93A mutant animals have diminished SNO-Hb (Alfred Hausladen,JSS unpublished data). B. RBCs derived from C93A mutant animals cannot effectively dilate blood vessels under hypoxia. C. Mice bearing RBCs with wildtype human Hb (C93) exhibit higher muscle oxygen level (pO2) compared to mice bearing mutant Hb unable to carry SNO at Cys93 (Cys93Ala). D. Mice bearing RBCs with mutant human Hb (C93) exhibit impaired autoregulation of blood flow in peripheral limbs. Panels B-D adapted from (Zhang et al., 2015).