Table 2.
Baseline Demographics and Characteristics
| Characteristics | rhNGF 180 μg/ml | Vehicle | Overall | P value |
|---|---|---|---|---|
| Number of subjects | 40 | 20 | 60 | |
| Age (years) | ||||
| Mean ± SD | 68.0 (13.98) | 62.2 (13.28) | 66.1 (13.92) |
0.1260a |
| Median (range) | 69.5 (22-89) | 59 (31-87) | 66 (22-89) | |
| <= 65 n (%) | 15 (37.5) | 12 (60.0) | 27 (45.0) | 0.0986b |
| > 65 n (%) | 25 (62.5) | 8 (40.0) | 33 (55.0) | |
| Gender, no. (%) | ||||
| Male n (%) | 26 (65.0) | 11 (55.0) | 37 (61.7) | 0.4526b |
| Female n (%) | 14 (35.0) | 9 (45.0) | 23 (38.3) | |
| Ethnicity, n (%) | ||||
| Hispanic, Latino, or Spanish | 2 (5.0) | 1 (5.0) | 3 (5.0) | 1b |
| Not Hispanic, Latino or Spanish | 38 (95.0) | 19 (95.0) | 57 (95.0) | |
| Race, n (%) | ||||
| Asian | 11 (27.5) | 5 (25.0) | 16 (26.7) | 0.5019c |
| Black or African American | 4 (10.0) | 4 (20.0) | 8 (13.3) | |
| White | 25 (62.5) | 10 (50.0) | 35 (58.3) | |
| American Indian or Alaska Native | - | - | - | |
| Native Hawaiian or Other Pacific Islander | - | - | - | |
| other | - | 1 (5.0) | 1 (1.7) | |
| Hypertension, no. (%) | 18 (45.0) | 9 (45.0) | 27 (45.0) | 1b |
| Diabetes mellitus, no. (%) | 4 (10.0) | 4 (20.0) | 8 (13.3) | 0.2827b |
| Study eye, n (%) | ||||
| Right | 22 (55.0) | 12 (60.0) | 34 (56.7) | 0.7125b |
| Left | 18 (45.0) | 8 (40.0) | 26 (43.3) | |
| IOP (mm Hg) | ||||
| Mean ± SD | 13.18 (4.7) | 15.15 (8.70) | 13.83 (6.31) | 0.2569a |
| Median (range) | 13 (6-48) | 13 (6-48) | 14 (6-48) | |
| Number of glaucoma medications | ||||
| Mean ± SD | 1.93 (0.86) | 2.25 (0.91) | 0.1808a | |
| Median (range) | 2 (1-4) | 2 (0-4) | ||
| Lens status | ||||
| Phakic | 18 (45.0) | 11 (55.0) | 0.465b | |
| Pseudophakic | 22 (55.0) | 9 (45.0) | ||
| BCVA ETDRS letters, mean ± SD | 73.23 (16.62) | 71.4 (13.06) | 0.6445a | |
BCVA = Best corrected visual acuity; IOP = Intraocular pressure; rhNGF = recombinant human nerve growth factor; SD = standard deviation
a
Student t-test
b
Fisher’s exact test
c
Exact permutation chi-square test