TABLE 1.
Genosubtypes, PFGE patterns, and sulfadiazine susceptibilities of W-135 meningococci isolated in Sweden between 1978 and 2000 in comparison with those of two 2000 hajj-associated reference strainsa
| Strain designation | Yr of isolation | Site of isolation | Genosubtype (VR1, VR2, VR3)b | PFGE type | Sulfadiazine susceptibility |
|---|---|---|---|---|---|
| 1 (608-9901) | 1979 | CSF | P1.5,2,36b | A | S |
| 2 (600-101) | 1980 | Blood | P1.5,2,36b | A | S |
| 3 (900-112) | 1987 | Nasopharynx | P1.5,2,36b | Unique | S |
| 4 (90-137) | 1994 | Blood | P1.5,2,36b | Unique | S |
| 5 (90-170) | 1995 | Joint fluid | P1.5,2,36b | Unique | S |
| 6 (90-66) | 1997 | Nasopharynx | P1.5,2,36b | B | S |
| 7 (90-68) | 1997 | Nasopharynx | P1.5,2,36b | B1 | S |
| 8 (90-71) | 1997 | Throat | P1.5,2,36b | B | S |
| 9 (90-7) | 1998 | Blood | P1.5,2,36b | Unique | R |
| 10 (90-188) | 1998 | Blood | P1.5,2,36b | Unique | R |
| 11 (90-410) | 1998 | Joint fluid | P1.5,2,36b | Unique | R |
| 12 (590-26) | 2000 | CSF | P1.5,2,36b | Unique | S |
| 13 (590-66)c | 2000 | CSF | P1.5,2,36b | C | R |
| 14 (590-75)c | 2000 | CSF | P1.5,2,36b | C | R |
| 15 (590-87)c | 2000 | Throat | P1.5,2,36b | C | R |
| 16 (590-95)c | 2000 | Throat | P1.5,2,36b | C | R |
| 17 (590-121) | 2000 | Blood | P1.5,2,36b | C | R |
| Ref 1 (M7089B)c | 2000 | CSF | P1.5,2,36b | C | R |
| Ref 2 (M7034)c | 2000 | Blood | P1.5,2,36b | C | R |
| 18 (600-773) | 1978 | Urogenital tract | P1.18a,3,38 | Unique | S |
| 19 (606-549) | 1978 | CSF | P1.18a,3,38 | Unique | S |
| 20 (606-396) | 1985 | Blood | P1.18a,3,38 | Unique | R |
| 21 (90-95) | 1990 | Bronchial | P1.18a,3,38 | Unique | S |
| 22 (90-193) | 1991 | Blood | P1.18a,3,38 | Unique | R |
| 23 (90-34) | 1993 | Blood | P1.18a,3,38 | Unique | R |
| 24 (90-142) | 1993 | Nasopharynx | P1.18a,3,38 | Unique | R |
| 25 (90-149) | 1995 | Nasopharynx | P1.18a,3,38 | D | R |
| 26 (90-122) | 1996 | Blood | P1.18a,3,38 | D1 | R |
| 27 (90-192) | 1998 | Throat | P1.18a,3,38 | E | R |
| 28 (90-193) | 1998 | Throat | P1.18a,3,38 | E | R |
| 29 (90-184) | 1998 | Blood | P1.18a,3,38 | E1 | R |
| 30 (90-272) | 1998 | Unknown origin | P1.18a,3,38 | F | S |
| 31 (90-274) | 1998 | Unknown origin | P1.18a,3,38 | F | S |
| 32 (590-194) | 1999 | Blood | P1.18a,3,38 | G | S |
| 33 (590-200) | 1999 | Throat | P1.18a,3,38 | G1 | S |
| 34 (590-49) | 2000 | Nasopharynx | P1.18a,3,38 | Unique | R |
| 35 (900-193) | 1987 | CSF | P1.5c,10a,36b | H1 | R |
| 36 (90-65) | 1990 | CSF | P1.5c,10a,36b | H | R |
| 37 (90-6) | 1996 | Blood | P1.5c,10a,36b | H | R |
| 38 (590-133) | 2000 | Blood | P1.5c,10a,36b | Unique | R |
| 39 (NK 793) | 1990 | Urogenital | P1.5a,2c,36b | I | S |
| 40 (90-76) | 1993 | Blood | P1.5a,2c,36b | I | S |
| 41 (90-105)d | 1996 | CSF | P1.5a,2c,36b | J | R |
| 42 (90-121)d | 1996 | CSF | P1.5a,2c,36b | J | R |
| 43 (90-55) | 1997 | Nasopharynx | P1.5a,10d,36b | Unique | R |
| 44 (90-106)e | 1995 | Throat | P1.7,16,35 | Unique | R |
| 45 (590-177) | 1999 | CSF | P1.7a,4a,37a | Unique | R |
| 46 (90-15)e | 1991 | Nasopharynx | P1.21,26-2,36bf | Unique | S |
a
CSF, cerebrospinal fluid; Ref, reference strain; R, resistant; S, sensitive.
b
Amino acid sequences of VR3: 35 (LIGSGSDQ), 36b (LLGSGSDE), 37a (LIGSATSDE), and 38 (LLGRIGDDDE).
c
Strains isolated from patients or carriers in Sweden; all were associated with returning Muslim pilgrims returning from the 2000 hajj as well as two reference strains from the 2000 hajj.
d
Serosubtyped as serosubtype P1.2.
e
Serosubtyped as serosubtype P1.16.
f
New VR2 variant found in the present study.