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. 2022 Jan 25;12:781100. doi: 10.3389/fimmu.2021.781100

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Copyright © 2022 Suhre, Sarwath, Engelke, Sohail, Cho, Whalen, Alvarez-Mulett, Krumsiek, Choi and Schmidt

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Analysis of 2D cluster pattern of all 253 beta values from the five studies is displayed. Coloring is based on beta values, with a higher abundancy in control in blue and a higher abundancy in COVID-19 in red. (B) Shown are 10 intergroup scatter plots of effect estimates from case vs. control ratios. Red indicates proteins that were Bonferroni significant at discovery level in one study (p < 0.05/2/Nprotein) and at replication level in the other (p < 0.05/Ndiscovery), where Nprotein ist the number of proteins tested and Ndiscovery the number of proteins reaching discovery significance in the first study. Green are proteins that reach nominal significance (p<0.05) in both studies. All other proteins are in blue (see Supplementary Data 1 for full summary statistics).