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. 2022 Jan 25;12:781100. doi: 10.3389/fimmu.2021.781100

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Copyright © 2022 Suhre, Sarwath, Engelke, Sohail, Cho, Whalen, Alvarez-Mulett, Krumsiek, Choi and Schmidt

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmap of 68 proteins differentially expressed across all five studies. Limited to proteins with similar trends (red: higher in case, blue: higher in controls), significance levels are indicated by ‘**‘ (p<0.05/253/5 = 4x10^-5, Bonferroni level), ‘*‘ (p<0.05/116 = 0.00043, replication level, as there were 116 Bonferroni significant associations), “. “ (p<0.05, nominal significance). Selected assigned pathways/groups are shown. Pathway information was retrieved form g:Profiler (*), Uniprot (#) or literature analyses (^). The g:Profiler analysis included only pathways from KEGG, Reactome and Wikipathway.