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. 2021 Nov 25;42(2):375–393. doi: 10.1007/s10875-021-01178-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Distribution of the length of unique post-selection (in-frame, in nucleotides) and pre-selection CDR3 sequences (out-of-frame, in nucleotides). Distributions of in-frame CDR3 length show a bias toward shorter lengths in atypical SCID (A) and AT (B) patients and longer lengths in ICF1 (C) and ICF2 (D) compared to all normal samples. Similar results are observed in out-of-frame CDR3 length which present a bias toward either shorter lengths in atypical SCID (E) and AT (F) patients or longer lengths in ICF1 (G) and ICF2 (H) compared to healthy donors. One-sided Wilcoxon Rank Sum Test for the significance of length difference between each group pair