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. 2022 Feb 7;13:714. doi: 10.1038/s41467-022-28399-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Structural comparison of active B2R (violet) with active M1R (light-blue, PDB ID: 6OIJ) and active H₁R (purple, PDB ID: 7DFL). DRY motif, NPxxY motif, PIF motif, and toggle switch were highlighted. b Structural comparison of active B2R with inactive M1R (yellow-orange, PDB ID: 5CXV), and inactive H₁R (teal, PDB ID: 3RZE). DRY motif, NPxxY motif, PIF motif, and toggle switch were highlighted with the interactions labelled by dotted lines.