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. 2022 Feb 7;5:113. doi: 10.1038/s42003-022-03053-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a–d Control: normal development. a Erk activity in DREKA embryos at 14 somite stage: dark nuclei point to high Erk activity. b The false color images represent the Erk activity averaged over a 30 μm perpendicular stack of images. c ISH against xirp2a (a marker of somite boundaries) in 30 hpf embryos. d IHC against Mesp2a, a marker of the last somite boundary at 14 somites (arrow). e–h Somitogenetic development in DREKA embryos incubated from one-cell stage in 10 μM DEAB in presence of 1 μM RA from the ten somite stage (arrow in g). e, f The Erk activity is high throughout the PSM. g ISH against xirp2a in 30hpf embryos. Somitogenesis is impaired past 13 somites (indicated by a *) with unclear somite boundaries. h IHC against Mesp2a show that it is not expressed past 13 somite stage (arrows in d and h). Scale bar: 50 μm.