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. 2022 Jan 25;12:786706. doi: 10.3389/fphar.2021.786706

FIGURE 3.

FIGURE 3

Predicted risk change for (A) the composite cardiovascular (CV) outcome consisting of non-fatal myocardial infarction, non-fatal stroke, or cardiovascular death in the total population; (B) the composite CV outcome in patients with UACR ≥30 mg/g; (C) the composite kidney outcome (doubling of serum creatinine or end-stage kidney disease) in the total population; and (D) the composite kidney outcome in patients with UACR ≥30 mg/g, (E) the composite CV outcome in patients with UACR <30 mg/g; (F) the composite kidney outcome in patients with UACR <30 mg/g based upon single and the multiple risk marker changes using the PRE score. Bars indicate the mean percentage reduction in the relative risk with 95% confidence intervals, following empagliflozin treatment. HbA1c, glycated hemoglobin; BP, blood pressure; UACR, urinary-albumin-creatinine-ratio; HDL, high-density-lipoprotein; LDL, low-density-lipoprotein; PRE score, Parameter Response Efficacy score.