. 2022 Jan 25;11:801691. doi: 10.3389/fonc.2021.801691

Table 1.

TBX3 targets and selection of genes involved in cell cycle progression, migration, and invasion. Fold changes < 2 or > -2 are indicated.

Genes	Upregulated	Downregulated
TBX3 targets	ID1\|SNAI2\|TWIST1\|BRAF (1,27)	CDKN2A\| CDKN1C (–1,68)\| CDKN1A (–1,26)
Cell cycle progression	CCNA2\|CCNB2\|CCNB1\|CCND2\|CCNE2\|CCNF\|CDK1\| CDK2\|CDK15\|CDC6\|CDC7\|CDC20\|CDC25B\|CDC45\| CDCA2\|CDCA3\|CDCA8\|PLK1\|TTK\|PTTG1\|MAD2L1\| CHEK1\|PCNA\|BUB1\|ORC6\|MCM5\|MCM3\|MCM2\| ID1\|AURKA\|AURKB\|MKI67\|FOXM1\|MYC (1,67)	CDKN2A\|CDKN2B\| CDKN1C (–1,68)\| CDKN1A (–1,26)
Migration	ZEB2\|SNAI2\|TWIST1\|GLI3\|ID1\|vimentin (1,52)\| CTNNB1 (1,22)	CDH6\|CDH10\|CDH13
Invasion	ADAM19\|ADAM33\|ADAMTS2\|ADAMTS5\|ADAMTS9\| ADAMTS14\|RUNX2\|MMP16\|MMP23A/B (1.69)\| MMP14 (1,63)\|MMP2 (1,5)\|MMP9 (1,03)	TIMP1