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. 2022 Jan 25;15:814287. doi: 10.3389/fncel.2021.814287

TABLE 1.

Stress effects on diffuse ECM components.

Stressor and timing Species/strain/
sex
Brain region ECM component effect* References
Maternal separation P2-14 (3 h daily) Rat/Wistar/male HIP Reelin decrease during development, increase in adulthood Zhang et al., 2013
Maternal separation P1- 14 (3 h daily) Rat/SD/male HIP Reelin increase in adulthood Wang et al., 2018
Corticosterone injection in adulthood Rat/SD/male HIP, PFC Reelin decrease in adulthood Lebedeva et al., 2020
Chronic unpredictable mild stress for 6 weeks in adulthood Mice/apoE/male HIP, PFC Reelin decrease in adulthood Zhang et al., 2021
Chronic unpredictable stress for 6 weeks in adulthood Rat/SD/male HIP, FC Laminin decrease Laifenfeld et al., 2005a
Social defeat during adolescence Mice/C57/male HIP, NAc Laminin decrease Rodríguez-Arias et al., 2017

*Compared to unstressed controls.

SD, Sprague Dawley; apoE, apolipoprotein E; FC, frontal cortex; HIP, hippocampus; PFC, prefrontal cortex; NAc, nucleus accumbens.