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. 2022 Jan 25;11:808396. doi: 10.3389/fonc.2021.808396

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Copyright © 2022 Kashima, Hishima, Okuma, Horio, Ogawa, Hayashi, Horiguchi, Motoi, Ushiku and Fukayama

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Normal adult thymus tissue stained with anti-CD70 antibody. Thymic medullary epithelial cells or dendritic cells were positive for CD70 (A, B). Immunostaining of CD70 in thymic squamous cell carcinoma (TSCC) (C). CD70-positivity was scored according to the proportion of positive tumor cells (score 0: <1%; score 1: 1–24%; score 2: 25–49%; score 3: 50–74%; score 4: 75–100%). Schematic summary of immunohistochemical analysis (D).The numbers indicate the positive cases of each staining. The numbers in the parentheses are the total number of the positive cases. Immunostaining of CD70 (score 4), CD5 and CD117 in TSCC (E). In contrast, thymoma showed the absence of CD70 expression (F). The CD70 score in lung squamous cell carcinoma was relatively low.