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. 2022 Jan 25;12:793992. doi: 10.3389/fimmu.2021.793992

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Copyright © 2022 Pagliarulo, Cheng, Brugger, van Dijk, van den Heijden, Levesque, Silina and van den Broek

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genes upregulated in TLS-high tumors are related to immune response activation, improved survival, and response to ICI. (A) Pathway enrichment analysis of TLS-associated DEGs unique to the d-TLS group comparison (n = 44) was performed using gene ontology “Biological Processes”. The number of corresponding DEGs is visualized for the top ten enriched processes (left). The contribution of specific genes to the top five enriched pathways is visualized (right). (B) Overall survival was compared for gene expression groups defined by cohort medians in the TCGA MIBC cohort (top row) and IMvigor210 cohort (bottom row) using Kaplan–Meier curve and log-rank test for each unique DEG. (C) Expression comparison of the identified unique DEGs between complete response (CR) and progressive disease (PD) after ICI in the IMVigor210 dataset was performed by two-tailed t-test. Genes that showed significant favorable prognostic associations in both cohorts are shown.