TABLE 1.

Summary of MRI in animal models of tauopathy.

Target	MRI sequence	Animal model	References
WM	DTI	pR5 mice	Massalimova et al., 2021; Soni et al., 2021
		rTg4510 mice	Sahara et al., 2014; Wells et al., 2015b; Colgan et al., 2016; Holmes et al., 2016
		TauRD/ΔK280 mice	Green et al., 2019
		Thy-Tau22	Degiorgis et al., 2020
		JNPL3 mice	Nishioka et al., 2019
		Tg601 mice	Hara et al., 2017
Tau	19F Shiga-X35	rTg4510 mice	Yanagisawa et al., 2018
	TauX, T1w-SE	PS19 mice	Badachhape et al., 2020; Parekh et al., 2021
Atrophy	T2	rTg4510 mice	Xie et al., 2010; Yang et al., 2011; Wells et al., 2015b; Holmes et al., 2016; Ishikawa et al., 2018; Ni et al., 2018; Ma et al., 2019; Barron et al., 2020; Park et al., 2020; Wang et al., 2020
		hTau mice	Hashimoto et al., 2019
		EC-tau mice	Fung et al., 2020
		pR5 mice	Kindler et al., 2021
		rTg21221 mice	Musi et al., 2018
		PS19 mice	Wu et al., 2019; Takeuchi et al., 2020; Lee et al., 2021
		R962-hTau rats	Malcolm et al., 2019
Texture	T2*w MRTA, T2*w	rTg4510 mice	Colgan et al., 2017; O’Callaghan et al., 2017
	QSM		O’Callaghan et al., 2017
Neurochemical profiles	1H MRS	rTg4510 mice	Yang et al., 2011; Kim et al., 2017
	1H, 13C MRS	pR5 mice	Nilsen et al., 2013
	CEST	Tau4RΔK (Tau) mice	Chen et al., 2021
		rTg4510 mice	Wells et al., 2015b; Holmes et al., 2016
		Tau4RΔK (Tau) mice	Chen et al., 2020
		hTau mice	Lauretti et al., 2017
		PS19 mice	Crescenzi et al., 2014, 2017
Optic nerve	T2	rTg4510 mice	Harrison et al., 2019
Fe, Ca	SWI	pR5 mice	Ni et al., 2020b
CVR	ASL	rTg4510 mice	Wells et al., 2015a
CMRO2	TRUST. PC	Tau4RΔK (Tau) mice	Wei et al., 2021
CBF	ASL	rTg4510 mice	Wells et al., 2015b; Holmes et al., 2016; Park et al., 2020
		PS19 mice	Park et al., 2020
		Tau.P301L mice	Govaerts et al., 2019
		pR5 mice	Kindler et al., 2021
		Tau4RΔK mice	Wei et al., 2021
BOLD	rs-fMRI	Thy-Tau22 mice	Degiorgis et al., 2020
		TauRD/ΔK280 mice	Green et al., 2019
		hTau.P301L mice	Detrez et al., 2020
	Task-based fMRI	rTg4510 mice	Nahavandi et al., 2017
Glymphatic system	DCE-MRI	rTg4510 mice	Harrison et al., 2020
Synaptic function	MEMRI	rTg4510 mice	Pautler et al., 2003; Perez et al., 2013; Majid et al., 2014; Fontaine et al., 2017; Bachstetter et al., 2020; Koren et al., 2020
		JNPL3 mice	Bertrand et al., 2013
		Tau-KO mice	Lopes et al., 2016
		Wtau-Tg mice	Kimura et al., 2007

ASL, arterial spin labeling; BOLD, blood-oxygenation-level-dependent; CBF, cerebral blood flow; CE, contrast enhanced; CEST, chemical exchange saturation transfer imaging; CMRO₂, cerebral metabolic rate of oxygen; CVR, cerebral vascular response; DCE, dynamic contrast enhanced; DTI, diffusion tensor imaging; fMRI, functional magnetic resonance imaging; ME, manganese enhanced; MRI, magnetic resonance imaging; MRS, magnetic resonance spectroscopy; MRTA, magnetic resonance texture analysis; PC, phase contrast; QSM, quantitative susceptibility mapping; rs, resting state; SE, spin echo; SWI, susceptibility-weighted imaging; TRUST, T₂ relaxation under spin tagging; WM, white matter; w, weighted.