Figure 1.

Gene expression of target genes selected for treatment of B cell malignancies

Gene expression was retrieved from an Illumina HT12.0 microarray dataset.²⁵ Per gene, the average MFI of samples is shown for different types of patient-derived (primary) B cell malignancies, BMMCs, B cells (CD19^pos), ALL cell lines, and EBV-LCLs. The final column represents the highest gene expression as measured in any healthy tissue other than B cells, PBMCs, and BMMCs as included in the microarray dataset and shown in Figure S1. Genes are clustered according to the type of B cell malignancy in which they are expressed (MFI ≥ 250). Abbreviations: MFI, mean fluorescence intensity; ALL, acute lymphoblastic leukemia; CLL, chronic lymphocytic leukemia; MM, multiple myeloma; BMMC, bone marrow mononuclear cells; EBV-LCL; Epstein-Barr virus-transformed lymphoblastoid cell lines.