Table 1.
Liver, lung, and serum iron indices in various mouse models
| C57BL/6 |
TFRC-KO |
Nude |
||||
|---|---|---|---|---|---|---|
| IA diet | ID diet | WT | KO | IA diet | ID diet | |
| Liver iron (μg/g) | 74.05 ± 6.2 | 48.10 ± 1.9∗∗ | 73.04 ± 10.0 | 43.62 ± 2.0∗ | 76.59 ± 6.6 | 51.32 ± 3.4∗∗ |
| Lung iron (μg/g) | 14.34 ± 3.3 | 4.21 ± 1.2∗ | N/A | N/A | 26.91 ± 3.9 | 14.39 ± 3.0∗ |
| Serum iron (μmol/L) | 27.62 ± 10.0 | 16.44 ± 2.8∗ | 29.07 ± 1.6 | 19.56 ± 1.4∗∗ | 51.12 ± 2.4 | 27.75 ± 3.1∗∗ |
| Serum TIBC (μmol/L) | 54.98 ± 4.1 | 53.10 ± 7.6 | 65.96 ± 1.5 | 54.82 ± 1.1∗∗ | 67.32 ± 2.7 | 57.74 ± 4.1 |
| Serum TS (%) | 51.03 ± 17.6 | 31.20 ± 5.8∗ | 46.96 ± 3.4 | 34.83 ± 3.1∗ | 71.33 ± 4.3 | 53.6 ± 3.0∗ |
| Serum ferritin (ng/mL) | 2247 ± 998.5 | 1869 ± 319.6 | 2490 ± 217.7 | 1608 ± 90.3∗∗ | 499.2 ± 77.4 | 520.7 ± 28.3 |
Note: All tissue and serum samples were obtained from HCC-bearing mice after perfusion at sacrifice. Data from orthotopically and intravenously injected mice were combined. n = 6, mean ± SD. ∗p < 0.05, ∗∗p < 0.01.