Figure 3.

Recovery from skin injury in a murine model of CLE is improved with nucleic acid-containing DAMP scavenger treatment

(A) Animals that received CDP and PAMAM G3 had a significantly lower score in injury severity. See Materials and methods for a description of scoring. Data represents mean ± standard error of the mean, ns represents a p ≥ 0.05, ∗∗ represents a p ≤ 0.01. (B–D) Recovery of skin lesions was improved in mice treated with (B) CDP and (C) PAMAM G3 compared with (D) saline, as evident by reduced thickening of the skin. (E–G) At higher magnification, reduction of panicular inflammation is observed with reduced immune cell infiltration in (E) CDP- and (F) PAMAM G3- compared with (G) saline-treated mice. (H–J) Fewer ulcerations and reduced pathologic thickening of the epidermis was observed in (H) CDP- and (I) PAMAM G3-treated mice than mice treated with (J) saline. Note the inclusion bodies found in PAMAM G3-treated mice (arrows, F), which do not appear in CDP- or saline-treated animals (E and G, respectively). Representative clinical photos of mice injury during treatment are shown in Figure S1.