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. 2021 Oct 19;30(2):763–781. doi: 10.1016/j.ymthe.2021.10.012

Figure 6.

Figure 6

Exosomes downregulated CF by delivering miR-34c-5p during pericyte activation and RIF

(A) (Left) Heatmap of exosomal miRNA and (right) histogram of miR-34c-5p at 0 h, 24 h, and 48 h. Data are the mean ± SD (n = 3). (B) Luciferase reaction between FUT8 and miR-34c-5p. Data are the mean ± SD (n = 3). (C) Representative morphological alterations in pericytes. Scale bar, 200 μm. Also shown are representative images of PDGFRβ (green) and α-SMA (red) staining, and α-SMA (green) and LCA (red) staining in vitro. The right panel shows the quantification. Scale bar, 75 μm. Data are the mean ± SD (n = 3). (D) Representative images of Masson's trichrome and PAS staining of UUO mouse kidney sections. Scale bar, 200 μm. Also shown are representative images of PDGFRβ (green) and α-SMA (red) staining, and α-SMA (green) and LCA (red) staining in vivo. The right panel shows the quantification. Scale bar, 75 μm. Data are the mean ± SD (n = 6).