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. 2021 Oct 19;30(2):763–781. doi: 10.1016/j.ymthe.2021.10.012

Figure 7.

Figure 7

CD81–EGFR complex formation aided miR-34c-5p entry into pericytes to downregulate CF

(A) (Top) Exosome and pericyte proteomics; (bottom) protein interaction network. (B) Computer simulation of CD81-EGFR molecular docking. (C) Representative images of EGFR (green) and CD81 (red) staining both in vitro (n = 3) and in vivo (n = 6). The right panel shows the quantification. Scale bar, 75 μm. Data are the mean ± SD. (D) Representative images of α-SMA (green), LCA (red), and miR-34c-5p (fam) staining in vitro. The right panel shows the quantification. Scale bar, 75 μm. (E) Representative images of α-SMA (green), LCA (red), and miR-34c-5p (fam) staining in vivo. The right panel shows the quantification. Scale bar, 75 μm. Data are the mean ± SD (n = 6).