Table 2. Baseline and post-treatment CLSS grade, depressed volume due to lipoatrophy, and skin elasticity.

Group		Baseline	Week 1	Week 4	Week 12	Week 24	P valuec
CLSS grade		2.24 ± 0.71	1.12 ± 0.32	1.20 ± 0.40	1.20 ± 0.40	1.28 ± 0.45	< 0.001
	Improvement rate, %a	-	50	46.4	46.4	42.9
	P valued	-	< 0.001	< 0.001	< 0.001	< 0.001
Depressed volume, mm3		21.37 ± 20.67	14.20 ± 14.10	14.48 ± 14.45	15.54 ± 14.79	15.55 ± 15.11	< 0.001
	Improvement rate, %a	-	32.9	31.2	26.1	25.4
	P valued	-	< 0.001	< 0.001	0.002	0.001
Skin elasticity, R2		0.62 ± 0.11	0.68 ± 0.14	0.63 ± 0.09	0.59 ± 0.10	0.63 ± 0.12	0.021
	Improvement rate, %b	-	9.3	1.0	−4.5	1.6
	P valued	-	0.033	0.677	0.101	0.623

Data are shown as mean ± SD. Statistically significant P values are in bold.

CLSS = Carruthers Lipoatrophy Severity Scale, R2 = percentage of viscoelasticity.

^aDefined as (baseline measurement − follow-up measurement)/baseline measurement × 100%; ^bDefined as (follow-up measurement − baseline measurement)/baseline measurement × 100%; ^cRepeated measures analysis of variance, with the Greenhouse-Geisser correction. P < 0.05 was considered significant; ^dPost-hoc analysis of each time point with the Wilcoxon signed rank test with the Bonferroni correction, where P < 0.010 was considered significant.