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Endomyocardial biopsy from a 18 years-old patient affected by a desmin-related restrictive cardiomyopathy, carrying a pace-maker for complete atrio-ventricular block. (A) Histologic section shows severe interstitial fibrosis and morphological myocytes' abnormalities with cellular hypertrophy and cytoplasmic vacuolization. (B,C) Transmission electron micrographs show multiple deposits of granulofilamentous material in the intermyofibrillar region.
