Figure 2.

LncRNAs regulate Mφs polarization in cancers. Many types of lncRNAs play important roles in cancers by acting on the M1 and M2 polarization processes of Mφs. (1) M1 polarization can resist tumor cells and play an immunomodulatory role in tumor microenvironments, such as gastric cancer, bladder cancer, and colorectal cancer. (2) M2 polarization promotes the growth, migration, and proliferation of tumor cells, and is involved in the progression of cancers, such as breast cancer, hepatocellular carcinoma, and osteosarcoma.