The combined strategy was effective in transgenic murine models of spontaneous thyroid cancer. A. Representative images of mouse thyroid tumors. B. Images of tumors from transgenic murine models. C. The weights of the mouse thyroid tumors were analyzed after treatment for 18 days; n=5, per group, *P<0.05, **P<0.01, ***P<0.001, compared with the Ctrl group, @P<0.05, @@P<0.01, @@@P<0.001, compared with the Comb group, ANOVA. D. Representative images and QuPath quantitation of p-ERK and Ki67 immunostaining of mouse thyroid tumors described above. *P<0.05, **P<0.01, ***P<0.001, compared with the Ctrl group, @P<0.05, @@P<0.01, @@@P<0.001, compared with the Comb group, ANOVA.