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Effect of CKLP1 on TGFβ2 ocular hypertensive mice. Once daily treatment with 5 mM CKLP1 significantly lowered IOP in TGFβ2 overexpressing mice by 20% (n = 6; P < 0.0001) when compared with the vehicle treated contralateral eye. IOP returned to baseline within 72 hours of cessation of treatment (n = 6; P = 0.1). Pretreatment refers to IOP measured before treating with CKLP1, but after injection of Ad.TGFβ2226/228 or control in the mice eyes.
