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. 2022 Feb 7;63(2):15. doi: 10.1167/iovs.63.2.15

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Figure 4. — Effect of CKLP1 treatment in DBA/2J mice. (A) DBA/2J mice (8–10 months old) treated with CKLP1 once daily for five consecutive days showed a 43% decrease in the IOP compared with baseline (P < 0.0001; n = 15). The IOP in the treated eyes returned to baseline levels within 72 hours after termination of treatment. (B) Histological analysis of the trabecular meshwork (TM) shows pigment dispersion-related anomalies, which are characteristics associated with this mouse strain (black arrows). No effects associated with CKLP1 treatment were noted. SC, Schlemm's canal.