Table 2.
Reported Adverse Reactions Within 7 Days After SARS-CoV-2 Vaccine Dose 1
| Total (N = 3316) | BNT162b2 (n = 1908) | mRNA-1273 (n = 1247) | Ad26.COV2.S (n = 161) | |
|---|---|---|---|---|
| Adverse reaction injection site | ||||
| Pain | 2183 (66) | 1218 (64) | 888 (71) | 77 (48) |
| Redness | 385 (12) | 147 (8) | 219 (18) | 19 (12) |
| Itching | 216 (7) | 85 (4) | 125 (10) | 6 (4) |
| Swelling | 383 (12) | 153 (8) | 218 (17) | 12 (7) |
| Tenderness | 2249 (68) | 1251 (66) | 905 (73) | 93 (58) |
| Warmth | 535 (16) | 257 (13) | 263 (21) | 15 (9) |
| Injection site reaction severity | ||||
| None | 435 (13) | 271 (14) | 118 (9) | 46 (29) |
| Mild | 2311 (70) | 1373 (72) | 842 (68) | 96 (60) |
| Moderate | 524 (16) | 241 (13) | 265 (21) | 18 (11) |
| Severe | 36 (1) | 16 (1) | 20 (2) | 0 (0) |
| Required ED visit vs hospitalization | 1 (0) | 1 (0) | 0 (0) | 0 (0) |
| Systemic adverse reactions | ||||
| Fever | 204 (6) | 86 (5) | 84 (7) | 34 (21) |
| Chills | 329 (10) | 137 (7) | 142 (11) | 50 (31) |
| Fatigue | 1532 (46) | 817 (43) | 608 (49) | 107 (66) |
| Headache | 1054 (32) | 564 (30) | 395 (32) | 95 (59) |
| Joint pain | 412 (12) | 192 (10) | 178 (14) | 42 (26) |
| Muscle aches | 673 (20) | 328 (17) | 283 (23) | 62 (39) |
| Nausea | 308 (9) | 157 (8) | 117 (9) | 32 (21) |
| Allergic reaction | 24 (1) | 15 (1) | 7 (1) | 2 (1) |
| Rash | 50 (2) | 23 (1) | 24 (2) | 3 (2) |
| Other | 220 (7) | 115 (6) | 89 (7) | 16 (10) |
| Systemic reaction severity | ||||
| None | 1382 (42) | 853 (45) | 493 (40) | 36 (22) |
| Mild | 1211 (37) | 714 (37) | 443 (36) | 54 (34) |
| Moderate | 595 (18) | 292 (15) | 247 (20) | 56 (35) |
| Severe | 86 (3) | 30 (2) | 41 (3) | 15 (9) |
| Required ED visit vs hospitalization | 9 (0) | 5 (0) | 4 (0) | 0 (0) |
Values are n (%).
Abbreviations: Ad26.COV2.S = Johnson & Johnson; BNT162b2 = Pfizer-BioNTech; ED = emergency department; mRNA-1273 = NIH-Moderna; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.