Table I.
Association between background characteristics of patients and intra-tumoral CD33 expression.
| Variable | CD33 low (n=322) | CD33 high (n=144) | P-value |
|---|---|---|---|
| Age, years | 69 (17–87) | 70 (34–86) | 0.5311 |
| Sex (male), n (%) | 235 (73.0) | 109 (75.7) | 0.5382 |
| BMI, kg/m2 | 23.0 (16.0-37.9) | 22.5 (14.2-32.6) | 0.8539 |
| HBs-Ag positive, n (%) | 47 (14.6) | 26 (18.1) | 0.3495 |
| HCV-Ab positive, n (%) | 166 (51.6) | 73 (50.7) | 0.8640 |
| Child-Pugh classification, grade B, n (%) | 11 (3.4) | 5 (3.5) | 0.9755 |
| Albumin, g/dl | 4.0 (2.1-5.1) | 3.9 (1.8-4.8) | 0.1193 |
| DCP, mAU/ml | 77 (2–250400) | 109 (9–89477) | 0.9493 |
| AFP, ng/ml | 7.4 (1–693700) | 28.1 (1–994600) | 0.1632 |
| Performing preoperative TACE or TAE, n (%) | 8 (2.5) | 6 (4.2) | 0.3256 |
| Tumor size, cm | 3.2 (0.9-30) | 3.7 (1–20) | 0.0216 |
| Multiple tumors, n (%) | 64 (19.9) | 36 (25.0) | 0.2131 |
| BCLC staging (B or C), n (%) | 45 (14.0) | 42 (29.2) | 0.0001 |
| Gross classification, single nodular type, n (%) | 208 (65.0) | 80 (55.9) | 0.0633 |
| Poorly differentiation, n (%) | 80 (24.9) | 63 (43.8) | <0.0001 |
| Microscopic vascular invasion, n (%) | 82 (25.5) | 61 (42.4) | 0.0003 |
| Microscopic intrahepatic metastasis, n (%) | 47 (14.6) | 36 (25.0) | 0.0070 |
| F3 or F4, n (%) | 141 (43.8) | 55 (38.5) | 0.2830 |
Data are presented as n (%) or median (range). BMI, body mass index; HBs-Ag, hepatitis B surface antigen; HCV-Ab, hepatitis C virus antibody; DCP, des-γ-carboxy prothrombin; AFP, α-fetoprotein; TA(C)E, transcatheter arterial (chemo)embolization; BCLC, Barcelona Clinic Liver Cancer.