Table III.

Results of univariate and multivariate analyses of recurrence-free survival.

	Univariate analysis			Multivariate analysis
Variable	HR	95% CI	P-value	HR	95% CI	P-value
Age	1.01	0.97-1.02	0.2481
Sex
Male (n=344)	1.28	0.96-1.71
Female (n=122)	1.00	(ref.)	0.0870
HBsAg
Positivity (n=73)	0.83	0.59-1.16
Negativity (n=392)	1.00	(ref.)	0.2709
HCVAb
Positive (n=239)	0.98	0.77-1.25
Negative (n=229)	1.00	(ref.)	0.8607
Alb	0.55	0.42-0.72	<0.0001	0.59	0.45-0.78	0.0001
DCP	1.00	1.00-1.00	0.0001	1.00	0.99-1.00	0.6709
AFP	1.00	1.00-1.00	<0.0001	1.00	1.00-1.00	<0.0001
Tumor size	1.09	1.06-1.12	<0.0001	1.05	1.01-1.09	0.0133
Macroscopic tumor numbers
Multiple (n=100)	1.94	1.48-2.55		1.33	0.952-1.87
Solitary (n=366)	1.00	(ref.)	<0.0001	1.00	(ref.)	0.0941
Poorly differentiated
Present (n=143)	1.81	1.41-2.33		1.23	0.925-1.65
Absent (n=322)	1.00	(ref.)	<0.0001	1.00	(ref.)	0.1524
Tumor types
Boundary type (n=288)	1.00	(ref.)		1.00	(ref.)
Nonboundary type (n=175)	1.50	1.17-1.90	0.0012	1.02	0.78-1.33	0.9106
Microscopic vascular invasion
Present (n=143)	1.90	1.48-2.44		1.19	0.89-1.60
Absent (n=323)	1.00	(ref.)	<0.0001	1.00	(ref.)	0.2480
Microscopic intrahepatic metastasis
Present (n=83)	3.11	2.33-4.17		1.72	1.17-2.55
Absent (n=382)	1.00	(ref.)	<0.0001	1.00	(ref.)	0.0060
Fibrosis
F0-2 (n=269)	1.00	(ref.)
F3, 4 (n=196)	1.11	0.87-1.41	0.4139
CD33-positive cell infiltration
High (n=144)	1.87	1.46-2.40		1.98	1.51-2.60
Low (n=322)	1.00	(ref.)	<0.0001	1.00	(ref.)	<0.0001
CD8-positive cell infiltration
High (n=219)	1.00	(ref.)		1.00	(ref.)
Low (n=247)	2.00	1.56-2.56	<0.0001	2.31	1.77-3.01	<0.0001

Parameters without subcategories are evaluated using continuous variables. HR, hazard ratio; CI, confidence interval; HBs-Ag, hepatitis B surface antigen; HCV-Ab, hepatitis C virus antibody; Alb, albumin; DCP, des-γ-carboxy prothrombin; AFP, α-fetoprotein; ref., reference.