Table 2.
Model | Rank | CHR | SNP | Position | P | Related gene | Genotype (patients) |
Genotype (controls) |
||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
A/A | A/B | B/B | A/A | A/B | B/B | |||||||
Trend | 1 | 8 | rs10086452 | 3691292 | 0.00001026 | CSMD1 | 2 | 48 | 141 | 18 | 107 | 156 |
Trend | 2 | 16 | rs12708686 | 25789460 | 0.00001532 | HS3ST4 | 5 | 70 | 116 | 28 | 133 | 121 |
Trend | 3 | 10 | rs688391 | 6529658 | 0.00001721 | PRKCQ | 59 | 105 | 27 | 61 | 126 | 95 |
Trend | 4 | 16 | rs9989408 | 25786610 | 0.0000198 | HS3ST4 | 8 | 76 | 107 | 34 | 140 | 108 |
Trend | 5 | 4 | rs4141270 | 106242441 | 0.00002805 | 44 | 95 | 52 | 33 | 126 | 122 | |
Trend | 6 | 4 | rs10518617 | 133841275 | 0.00003039 | 29 | 84 | 78 | 15 | 107 | 159 | |
Trend | 7 | 20 | rs4811012 | 48294701 | 0.00003177 | 3 | 58 | 130 | 22 | 116 | 144 | |
Trend | 8 | 15 | rs6493688 | 29560167 | 0.00003323 | 40 | 89 | 62 | 25 | 124 | 133 | |
Trend | 9 | 12 | rs10844159 | 32288782 | 0.00003414 | BICD1 | 21 | 81 | 89 | 10 | 94 | 178 |
Trend | 10 | 1 | rs10803183 | 242444561 | 0.00003789 | 5 | 58 | 128 | 6 | 36 | 240 | |
Trend | 11 | 13 | rs4773840 | 94568426 | 0.00004323 | ABCC4 | 22 | 80 | 89 | 10 | 96 | 176 |
Trend | 12 | 14 | rs11621135 | 70729362 | 0.00004646 | 10 | 65 | 115 | 2 | 66 | 214 | |
Trend | 13 | 17 | rs2958927 | 50314685 | 0.00004719 | 29 | 81 | 77 | 17 | 104 | 161 | |
Trend | 14 | 13 | rs1678353 | 94547567 | 0.00004959 | ABCC4 | 23 | 81 | 87 | 9 | 103 | 170 |
Trend | 15 | 10 | rs4749828 | 9062151 | 0.00004966 | 15 | 80 | 95 | 6 | 89 | 187 | |
Trend | 16 | 7 | rs12700309 | 21850980 | 0.00005138 | DNAH11 | 57 | 99 | 35 | 48 | 144 | 90 |
Trend | 17 | 10 | rs17784350 | 50512270 | 0.00005223 | CHAT | 7 | 61 | 123 | 25 | 127 | 130 |
Trend | 18 | 2 | rs2693818 | 6121959 | 0.0000536 | 31 | 80 | 79 | 59 | 166 | 57 | |
Trend | 19 | 11 | rs6265 | 27636492 | 0.00005366 | BDNF-AS1,BDNF | 40 | 107 | 44 | 34 | 136 | 112 |
Trend | 19 | 11 | rs11030104 | 27641093 | 0.00005366 | BDNF-AS1,BDNF | 40 | 107 | 44 | 34 | 136 | 112 |
Dominant | 1 | 2 | rs2693818 | 6121959 | 0.0000009002 | 31 | 80 | 79 | 59 | 166 | 57 | |
Dominant | 2 | 2 | rs6718476 | 6112647 | 0.0000009454 | 31 | 81 | 79 | 59 | 166 | 57 | |
Dominant | 3 | 10 | rs688391 | 6529658 | 0.000001239 | PRKCQ | 59 | 105 | 27 | 61 | 126 | 95 |
Dominant | 4 | 10 | rs604663 | 6544132 | 0.000002684 | PRKCQ | 52 | 110 | 29 | 57 | 128 | 97 |
Dominant | 5 | 1 | rs10803183 | 242444561 | 0.000005297 | 5 | 58 | 128 | 6 | 36 | 240 | |
Dominant | 6 | 11 | rs1488830 | 27593461 | 0.00003125 | BDNF-AS1 | 53 | 107 | 31 | 54 | 134 | 94 |
Dominant | 7 | 18 | rs12964456 | 30023916 | 0.00003475 | NOL4 | 17 | 56 | 118 | 20 | 143 | 118 |
Dominant | 8 | 4 | rs6531299 | 33872088 | 0.00003526 | 14 | 82 | 95 | 14 | 74 | 194 | |
Dominant | 9 | 20 | rs6133220 | 551620 | 0.00003676 | 36 | 114 | 41 | 38 | 132 | 112 | |
Dominant | 10 | 2 | rs941009 | 6058737 | 0.00003957 | 25 | 83 | 83 | 54 | 157 | 71 | |
Dominant | 11 | 1 | rs6656194 | 164031638 | 0.00004554 | 33 | 98 | 60 | 29 | 111 | 142 | |
Dominant | 12 | 7 | rs6461595 | 21724570 | 0.0000477 | DNAH11 | 41 | 111 | 39 | 53 | 122 | 107 |
Dominant | 13 | 8 | rs2433150 | 6489560 | 0.00005107 | 5 | 40 | 146 | 13 | 104 | 165 | |
Dominant | 14 | 13 | rs9532107 | 37187961 | 0.00005386 | TRPC4 | 14 | 67 | 110 | 33 | 140 | 109 |
Dominant | 15 | 2 | rs10204095 | 57652544 | 0.0000553 | 5 | 37 | 148 | 10 | 101 | 166 | |
Dominant | 16 | 4 | rs7670109 | 184691188 | 0.00005679 | 38 | 87 | 66 | 74 | 157 | 51 | |
Dominant | 17 | 6 | rs13196989 | 184373 | 0.00005703 | 8 | 74 | 108 | 10 | 61 | 211 | |
Dominant | 18 | 3 | rs7610425 | 150967983 | 0.00005804 | ANKUB1 | 9 | 90 | 92 | 11 | 82 | 189 |
Dominant | 19 | 2 | rs12468070 | 6077432 | 0.00006067 | 25 | 84 | 82 | 56 | 155 | 71 | |
Dominant | 20 | 14 | rs2167151 | 78933086 | 0.00006216 | NRXN3 | 17 | 84 | 90 | 14 | 82 | 186 |
Recessive | 1 | 1 | rs4520412 | 15232554 | 0.0000008571 | KAZN | 25 | 110 | 56 | 92 | 115 | 75 |
Recessive | 2 | 11 | rs1519480 | 27632288 | 0.000002159 | BDNF-AS1 | 0 | 61 | 130 | 25 | 101 | 156 |
Recessive | 3 | 6 | rs3777799 | 133631276 | 0.000003063 | EYA4 | 22 | 54 | 111 | 4 | 93 | 185 |
Recessive | 4 | 8 | rs12545634 | 26929236 | 0.00001289 | 39 | 77 | 75 | 19 | 121 | 142 | |
Recessive | 5 | 2 | rs10205827 | 75356361 | 0.00002183 | 10 | 102 | 79 | 52 | 122 | 107 | |
Recessive | 6 | 2 | rs10208470 | 75356624 | 0.00002186 | 10 | 102 | 79 | 52 | 122 | 108 | |
Recessive | 7 | 7 | rs12538837 | 97522404 | 0.00004215 | 27 | 111 | 53 | 86 | 128 | 68 | |
Recessive | 8 | 8 | rs10086635 | 26955860 | 0.00004484 | 48 | 76 | 67 | 30 | 142 | 110 | |
Recessive | 9 | 4 | rs6826653 | 19736139 | 0.00004904 | 15 | 55 | 121 | 2 | 84 | 196 | |
Recessive | 10 | 2 | rs9309489 | 75355228 | 0.00004915 | 11 | 101 | 79 | 52 | 122 | 108 | |
Recessive | 11 | 10 | rs2026432 | 6547609 | 0.00004948 | PRKCQ | 25 | 106 | 60 | 81 | 130 | 71 |
Recessive | 12 | 13 | rs9521844 | 110018508 | 0.00005096 | 0 | 61 | 130 | 19 | 94 | 169 | |
Recessive | 13 | 9 | rs10959456 | 11002926 | 0.00005841 | 0 | 66 | 120 | 19 | 105 | 158 | |
Recessive | 14 | 8 | rs9314506 | 3682052 | 0.00007367 | CSMD1 | 25 | 102 | 64 | 80 | 131 | 71 |
Recessive | 15 | 13 | rs9555965 | 89459182 | 0.00007841 | 39 | 72 | 80 | 22 | 121 | 139 | |
Recessive | 15 | 13 | rs9555966 | 89460007 | 0.00007841 | 39 | 72 | 80 | 22 | 121 | 139 | |
Recessive | 17 | 6 | rs13203299 | 169184034 | 0.00008602 | 33 | 68 | 90 | 16 | 122 | 144 | |
Recessive | 18 | 11 | rs12291063 | 27650677 | 0.00009339 | BDNF-AS1,BDNF | 0 | 53 | 138 | 18 | 92 | 172 |
Recessive | 19 | 22 | rs7290832 | 25658787 | 0.00009952 | 38 | 81 | 72 | 21 | 149 | 112 | |
Recessive | 20 | 9 | rs871095 | 138095067 | 0.0001101 | NACC2 | 41 | 93 | 57 | 24 | 145 | 113 |
Model, the genetic model in which candidate SNPs were selected by GWAS; CHR, chromosome number.Related gene, the nearest gene from the SNP site; A/A, homozygote for the minor allele in each SNP.A/B, heterozygote for the major allele in each SNP; B/B, homozygote for the major allele in each SNP.