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. 2021 Mar 8;17:1744806921999924. doi: 10.1177/1744806921999924

Table 5.

Top 20 candidate gene sets selected from gene-set analysis for patients with postherpetic neuralgia (PHN).

Model Rank Gene set name nGenes Beta SE P Pa
Trend 1 go_regeneration 153 0.308 0.0685 0.0000033672 0.0358741488*
Trend 2 go_reactive_oxygen_species_metabolic_process 92 0.411 0.0922 0.0000042685 0.045476599*
Trend 3 go_organ_regeneration 79 0.355 0.0966 0.00011875 1
Trend 4 reactome_p2y_receptors 12 1.03 0.282 0.0001333 1
Trend 5 tuomisto_tumor_suppression_by_col13a1_up 16 0.771 0.215 0.00016802 1
Trend 6 go_regulation_of_mrna_3_end_processing 27 0.494 0.141 0.00023174 1
Trend 7 go_au_rich_element_binding 21 0.655 0.192 0.00032672 1
Trend 8 go_regulation_of_nuclear_transcribed_mrna_poly_a_tail_shortening 11 0.765 0.226 0.00035697 1
Trend 9 go_rna_destabilization 16 0.601 0.178 0.00037747 1
Trend 10 go_apical_protein_localization 12 0.826 0.251 0.00050398 1
Trend 11 murakami_uv_response_6hr_dn 19 0.637 0.195 0.00053107 1
Trend 12 go_superoxide_metabolic_process 30 0.623 0.19 0.00053228 1
Trend 13 go_negative_regulation_of_cellular_response_to_insulin_stimulus 31 0.513 0.159 0.00060983 1
Trend 14 go_execution_phase_of_apoptosis 53 0.375 0.117 0.00068738 1
Trend 15 hernandez_aberrant_mitosis_by_docetacel_4nm_up 21 0.624 0.196 0.00072487 1
Trend 16 go_regulation_of_mrna_polyadenylation 10 0.629 0.198 0.00074015 1
Trend 17 pid_nfat_tfpathway 47 0.401 0.13 0.00099145 1
Trend 18 go_regulation_of_transferase_activity 920 0.0867 0.0283 0.0010735 1
Trend 19 go_axon 411 0.125 0.0413 0.0012388 1
Trend 20 go_regulation_of_cellular_amide_metabolic_process 344 0.136 0.0449 0.0012506 1
Dominant 1 go_arachidonic_acid_monooxygenase_activity 15 1.33 0.269 0.00000041113 0.00438017902*
Dominant 2 reactome_p2y_receptors 12 1.23 0.294 0.000015196 0.161898184
Dominant 3 go_regulation_of_mrna_polyadenylation 10 0.791 0.206 0.000061699 0.657341146
Dominant 4 go_regulation_of_mrna_3_end_processing 27 0.551 0.147 0.000088695 0.94495653
Dominant 5 go_long_chain_fatty_acid_metabolic_process 87 0.342 0.0913 0.000090289 0.961939006
Dominant 6 go_negative_regulation_of_binding 127 0.273 0.074 0.00011268 1
Dominant 7 go_neuron_apoptotic_process 34 0.522 0.143 0.0001309 1
Dominant 8 go_reactive_oxygen_species_metabolic_process 92 0.347 0.0961 0.00015146 1
Dominant 9 murakami_uv_response_6hr_dn 19 0.724 0.203 0.00017847 1
Dominant 10 graham_normal_quiescent_vs_normal_dividing_up 64 0.433 0.122 0.00019318 1
Dominant 11 go_regeneration 153 0.252 0.0713 0.000204 1
Dominant 12 reactome_signaling_by_notch4 12 0.933 0.264 0.00020967 1
Dominant 13 tuomisto_tumor_suppression_by_col13a1_up 16 0.772 0.224 0.00028268 1
Dominant 14 go_arachidonic_acid_metabolic_process 50 0.424 0.126 0.00036618 1
Dominant 15 go_rna_destabilization 16 0.626 0.186 0.00038011 1
Dominant 16 17 0.667 0.2 0.00041978 1
Dominant 17 go_negative_regulation_of_cellular_response_to_insulin_stimulus 31 0.548 0.165 0.00044684 1
Dominant 18 reactome_xenobiotics 15 0.868 0.273 0.00073068 1
Dominant 19 go_apical_protein_localization 12 0.83 0.262 0.00075723 1
Dominant 20 go_neuron_death 46 0.4 0.127 0.00080182 1
Recessive 1 go_translation_regulator_activity_nucleic_acid_binding 17 1.06 0.226 0.0000013818 0.0147216972*
Recessive 2 galluzzi_permeabilize_mitochondria 41 0.546 0.13 0.000014119 0.150423826
Recessive 3 go_fructose_metabolic_process 14 1.06 0.258 0.000020033 0.213431582
Recessive 4 go_regulation_of_hexokinase_activity 11 0.995 0.253 0.000043055 0.45870797
Recessive 5 go_immunoglobulin_binding 18 0.719 0.191 0.000084426 0.899474604
Recessive 6 go_heat_shock_protein_binding 88 0.329 0.0876 0.000088017 0.937733118
Recessive 7 go_peptide_antigen_binding 25 0.795 0.216 0.00011626 1
Recessive 8 go_ikappab_kinase_complex 11 1.02 0.282 0.0001527 1
Recessive 9 mootha_glycolysis 21 0.771 0.215 0.00016298 1
Recessive 10 kang_immortalized_by_tert_up 86 0.318 0.0922 0.00028655 1
Recessive 11 bogni_treatment_related_myeloid_leukemia_up 29 0.553 0.163 0.00033607 1
Recessive 12 go_igg_binding 7 0.947 0.281 0.00037687 1
Recessive 13 ellwood_myc_targets_up 13 0.839 0.249 0.00038154 1
Recessive 14 dorsam_hoxa9_targets_up 35 0.449 0.138 0.0005898 1
Recessive 15 reactome_abortive_elongation_of_hiv1_transcript_in_the_absence_of_tat 23 0.64 0.201 0.00073176 1
Recessive 16 krieg_hypoxia_not_via_kdm3a 716 0.109 0.0343 0.00073919 1
Recessive 17 go_central_nervous_system_development 841 0.0994 0.0316 0.00084853 1
Recessive 18 shin_b_cell_lymphoma_cluster_9 19 0.659 0.212 0.0009452 1
Recessive 19 go_regulation_of_protein_sumoylation 21 0.596 0.192 0.00094559 1
Recessive 20 holleman_daunorubicin_b_all_up 10 1.16 0.374 0.00097434 1

Model, the genetic model in which candidate gene sets were selected by analysis; nGenes, the number of genes in the data that are in the gene set; Beta, the regression coefficient of the gene set; SE, the standard error of the regression coefficient; Pa, adjusted P-value for multiple testing.

*Significant association after the conservative Bonferroni correction.