Table 5. Problems and challenges in the withdrawal of a β-lactam allergy label.

– Too few allergists with experience in this field

– Rare allergological testing in children

– Patients avoid β-lactams despite withdrawal of suspected diagnosis

– Duration and conditions of provocation testing are not standardised

– Laboratory tests for the detection of β-lactam allergy not sufficiently validated

– Skin testing is time-consuming, cost-intensive, and β-lactams are largely not approved for this indication (skin testing)

– Cross-reactivities between β-lactam antibiotics not fully known

– Regional differences in the triggering β-lactams and diagnostic procedures in Europe.