Figure 3.
Metabolic imaging of the normal human brain at 3 T with hyperpolarised carbon-13 MRI following intravenous injection of hyperpolarised carbon-13 labelled pyruvate. The formation of hyperpolarised carbon-13 labelled lactate is shown along with the apparent exchange rate constant (kP measured in s-1) describing the reaction catalysed by the enzyme LDH. Hyperpolarised carbon-13 labelled bicarbonate can also be detected due to mitochondrial metabolism of the pyruvate. Figure adapted from Grist et al31. LDH, lactate dehydrogenase.