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. 2022 Jan 25;8:808233. doi: 10.3389/fvets.2021.808233

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Copyright © 2022 Bao, Liang, Sun, Mohyuddin, Chen, Wen, Yong, Ma, Yu, Ju and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytotoxicity of baicalin in IPEC-J2 cells and the effect of baicalin on the viability of IPEC-J2 cells stimulated with LPS. Baicalin at 4 μg/mL increased the viability of IPEC-J2 cells, whereas 16 μg/mL baicalin was not cytotoxic to IPEC-J2 cells. Meanwhile, baicalin at concentrations of ≥ 64 μg/mL was significantly cytotoxic (A). LPS stimulation decreased IPEC-J2 cell viability, and this effect alleviated by baicalin pretreatment (B). Data are presented as the mean ± SEM (n = 6 per treatment, *p < 0.05 compared to the model group). CON, control; L-Bai, low-concentration baicalin; M-Bai, middle-concentration baicalin; H-Bai, high-concentration baicalin.