TABLE 1.
The list of lncRNA‐RBP interaction network in cancer proliferation and apoptosis
| lncRNA | RBP | Cancer type | Function* | Mechanism | Reference |
|---|---|---|---|---|---|
| OCC‐1 | HuR | Colorectal cancer | Proliferation ↓ | Enhances the ubiquitination and degradation of HuR to regulate mRNAs related to the growth of cancer cells | [77] |
| CASC9 | HNRNPL | Hepatocellular carcinoma | Proliferation ↑, apoptosis ↓ | Regulates a joint set of target genes associated with PI3K/AKT signaling and DNA damage signaling | [79] |
| HOXA11‐AS | EZH2, LSD1 | Gastric cancer | Proliferation, migration and invasion ↑ | Serves as a scaffold to facilitate the formation of EZH2 and LSD1 protein complex and inhibit the expression of PRSS8 | [80] |
| FEZF1‐AS1 | PKM2 | Colorectal cancer | Proliferation and metastasis ↑ | Enhances the STAT3 signaling and aerobic glycolysis (Warburg effect) | [81] |
| CYTOR | NCL, Sam68 | Colorectal cancer | Proliferation and metastasis ↑ | Activates the NF‐κB signaling pathway and EMT | [82] |
| ANRIL | EZH2 | Non‐small cell lung cancer | Proliferation ↑, apoptosis ↓ | Silences the transcriptional level of KLF2 and p21 | [83] |
| TINCR | STAU1 | Gastric cancer | Proliferation ↑, apoptosis ↓ | Affects the stability and expression of KLF2 mRNA | [89] |
| APOC1P1‐3 | α‐tubulin | Breast cancer | Apoptosis ↓ | Increases the acetylation level of α‐tubulin | [90] |
| MALAT‐1 | HMGB1 | Multiple myeloma | Autophagy ↑, apoptosis ↓ | Promotes the expression level of HMGB1 at the post‐translational level | [91] |
| LINC00460 | EZH2 | Colorectal cancer | Proliferation ↓, apoptosis ↑ | Suppresses KLF1 expression | [65] |
| P53RRA | G3BP1 | Lung cancer | Apoptosis ↑ | Activates the p53 pathway | [92] |
| NEAT1 | SFPQ | Chronic myeloid leukemia | Apoptosis ↑ | Limits the effectiveness of SFPQ | [94] |
↑ and ↓ indicate increase and decrease, respectively.
Abbreviations: lncRNA, Long non‐coding RNA; RBP, RNA‐binding proteins; HNRNPL, Heterogeneous nuclear ribonucleoprotein L; EZH2, Enhancer of zeste homolog 2; LSD1, Lysine demethylase 1A; PKM2, Pyruvate kinase M2;NCL, Nucleolin; EZH2, Enhancer of zeste homolog 2; STAU1,Staufen1; HMGB1, High mobility group box 1; EZH2, Enhancer of zeste homolog 2; G3BP1, GTPase‐activating protein‐binding protein 1; SFPQ, Splicing factor proline/glutamine‐ric; PRSS8, Recombinant protease, serine 8; STAT3, Signal transducer and activator of transcription 3; EMT, Epithelial‐mesenchymal transition; NF‐κB, Nuclear factor‐kappa B; KLF2, Kruppel like factor 2.