TABLE 2.
The list of lncRNA‐RBP interaction network in cancer metastasis and drug resistance
| lncRNA | RBP | Cancer type | Function* | Mechanism | Reference |
|---|---|---|---|---|---|
| CASC9 | CBP | Esophageal cancer | Metastasis ↑ | Upregulates LAMC2 expression by binding with CBP and modifying histone acetylation | [60] |
| CALIC | hnRNP‐L | Colon cancer | Metastasis ↑ | Induces the expression of AXL by binding hnRNP‐L | [99] |
| SNHG7 | EZH2 | Ovarian cancer | Migration and invasion ↑ | Inhibits the expression of KLF2 by binding EZH2 | [100] |
| DRAIC | UCHL5 | Gastric cancer | Proliferation and metastasis ↓ | Promotes the degradation of NFRKB by attenuating binding of UCHL5 and NFRKB | [73] |
| TPT1‐AS1 | NF90 | Colorectal cancer | Metastasis ↑ | Enhances the association between NF90 and VEGFA mRNA | [101] |
| lncRNA‐HIT | ZEB1 | Non‐small cell lung cancer | Invasion and migration ↑ | Binds to ZEB1 and regulates the stability of ZEB1 | [102] |
| LINC01133 | SRSF6 | Colorectal cancer | Metastasis ↓ | Binds to SRSF6 to inhibit EMT | [103] |
| MIR155H | PTBP1 | Glioma | Endows gliomas with chemical resistance to TMZ | Activates the Wnt/β‐Catenin pathway | [112] |
| HOTAIR | ER | Breast cancer | Contributes to tamoxifen resistance | Promotes ligand‐independent ER activities | [29] |
| AFAP1‐AS1 | AUF1 | Breast cancer | Induce trastuzumab resistance | Enhances the translation activity of ERBB2 | [111] |
| SRLR | NF‐κB | Renal cell carcinoma | Elicits intrinsic sorafenib resistance | Promotes IL‐6 transcription and activates the STAT3 pathway | [113] |
| HOXD‐AS1 | WDR5 | Prostate cancer | Promotes chemo‐resistance | Regulates the expression of target genes by mediating H3K4me3 | [114] |
| AGAP2‐AS1 | CBP | Breast cancer | Promotes the drug resistance of trastuzumab | Up‐regulates the expression of MyD88 and activating NF‐κB signal pathway | [116] |
*
↑ and ↓ indicate increase and decrease, respectively.
Abbreviations: CBP, CREB binding protein; EZH2, Enhancer of zeste homolog 2; UCHL5, Ubiquitin C‐Terminal hydrolase L5; NF90, Nuclear factor 90; ZEB1, Zinc finger E‐Box binding homeobox 1; SRSF6, Serine and arginine rich splicing factor 6; PTBP1, Polypyrimidine tract binding protein 1; ER, Estrogen receptor; AUF1, AU‐binding factor 1; NF‐κB, Nuclear factor kappa‐B; WDR5, WD repeat domain 5; CBP, CREB binding protein.