TABLE 3.

Applications of ferroptosis in cancer

Compound/Drug	Cancer type	Target	Function	Reference
Sulfasalazine	Lung cancer, Glioblastoma, Colorectal cancer, Pancreatic cancer, Prostate cancer	SLC7A11	Inhibit cysteine uptake and GPX4 synthesis, promote ferroptosis	[47, 128, 147, 150]
Cisplatin	Lung cancer, Colorectal cancer	GSH	Induce Lipid peroxidation, increase the level of free iron,	[134, 138]
Dihydroartemisinin	Lung cancer, Glioblastoma, Colorectal cancer, Breast cancer	Ferritinophagy	Induce Iron metabolism	[139]
Statins	Lung cancer	GPX4	Block the synthesis of GPX4	[140]
Gefitinib	Lung cancer	ROS	Inhibition of EGFR‐ERK/AKT by gefitinib, reduces ROS	[155]
Sorafenib	Glioblastoma, Hepatocellular carcinoma, Liver Cancer, Colorectal cancer	SLC7A11	Induce lipid peroxidation, accumulation of ROS to promote ferroptosis	[95, 143, 144]
Lapatinib	Breast Cancer, Glioblastoma	Fe	Induces ferroptosis by elevating the intracellular iron level	[156]
Temozolomide	Glioblastoma	NRF2/ATF4	Induce the expression of SLC7A11	[142]
Artesunnate	Glioblastoma, Pancreatic cancer, Ovarian cancer	Ferritin	Enhance lysosomal degradation of ferritin	[151, 153, 157]
Paclitaxel	Colorectal cancer	P53, SLC7A11	Lipid peroxidation	[158]
Siramesine	Breast cancer	Iron	increases iron	[135]
Gemcitabine	Pancreatic cancer	GPX4	Inhibit lipid peroxidation	[159]
Tanshinone	Pancreatic cancer	STAT3	Regulating ferroptosis through lysosome pathway	[160]
Cotylenin A	Pancreatic cancer	ROS	Promoting ROS production	[161]

Abbreviations: SLC7A11, cystine/glutamate antiporter solute carrier family 7 member 11; GSH, glutathione; GPX4, glutathione peroxidase 4; ROS, reactive oxygen species; ATF4, Activating transcription factor 4; NRF2, NFE2‐related factor 2; STAT3, signal transducer and activator of transcription 3; ROS, reactive oxygen species; EGFR, epidermal growth factor receptor; ERK, extracellular signal‐regulated kinase; AKT, protein kinase B.