Figure 4.

ERBB phosphorylation in cells overexpressing ERBB. (a) ERBB expression levels (upper) and immunofluorescence images of overexpressed ERBB (lower) in the indicated cells. The locations of the cells are shown in Fig. S2a. The expression level of each ERBB was normalized to that in wild-type cells. Error bars, SE. Scale bar, 50 μm. (b) EGF or HRG induced ERBB phosphorylation in wild-type (wt) and ERBB-overexpressing (OE) cells. The red dotted rectangles indicate phosphorylated ERBB bands. (c) Fold change of the ERBB phosphorylation. Crosses and open circles respectively show experimental observations and results obtained from the global model fitting.