Figure 5.

Ligand effects on the phosphorylation and dimerization networks. (a) Phosphorylation networks. The black network in the middle shows effective phosphorylation rates on the edges, each of which is defined as the ratio of the dimer phosphorylation rate to the dephosphorylation rate. The left (red) and right (blue) networks represent multipliers on the effective rates owing to EGF and HRG stimulation, respectively. (b) Dimerization networks. The black network in the middle shows effective dimerization rates on the edges, each of which is defined as the ratio of the dimerization rate to the dissociation rate. The left (red) and right (blue) networks represent multipliers on the effective rates owing to EGF and HRG stimulation, respectively.