Figure 6.

The diversity of phosphorylation patterns. (a) The receptor expression patterns (the leftmost column) and phosphorylation patterns obtained from the originally estimated parameters (unsymmetric kinetics; Unsym), symmetrized dimerization-associated parameters (D-sym), symmetrized phosphorylation-associated parameters (P-sym), and symmetrized phosphorylation- and dimerization-associated parameters (PD-sym). For the phosphorylation pattern, the averages of the fold changes over 100 sets of estimated parameters (generated by the MCMC method) are shown. (b) The response number against the threshold value used to discretize the fold change for Unsym, D-sym, P-sym, PD-sym, and random kinetics. (c) The number of response patterns for 3⁴ expression levels, where each ERBB subtype expression level is taken from one of (20, 100, 500), and for 6⁴ expression levels, where each ERBB subtype expression level is taken from one of (20, 43, 95, 210, 460, 1000). In (b) and (c), the solid curves represent the averages over 100 sets of estimated parameters, and the shaded regions indicate the standard deviations.