Fig. 5.

Neurocognitive outcome as assessed by the Cambridge Neuropsychological Test Automated Battery (CANTAB). Individualized Z-scores (number of SD below or above the pre-infection mean) were generated for each animal at each assessment post-ZIKV inoculation (A). Impairment (shaded in red) is defined as > 2.5 SD reduction in accuracy for both Motor Screening Task (MOT) and Self-Ordered Spatial Search (SOSS), > 2.5 SD reduction in the number of MOT performed within 10 min or > 2.5 SD increase in time to complete 40 SOSS tasks. Sex, age, timing of occurrence of and the number of impairments recorded are listed for each individual animal (B). * Indicates the two animals that had detectable ZIKV RNA in the brain. Impairment on SOSS accuracy (filled symbols) followed the peaking of CSF HLA-DR + CD38 + CD8 T cells (open symbols) in 3 of 4 animals in the Late group (C). Each color represents data from individual animals as listed in Fig. 1B, animals in the early group are represented by circles and the late group by squares