Fig. 7.

Detailed analysis of active RRMS patients. A Comparison of total CNS-EEV concentrations of active RRMS patients who had received steroids within 35 days prior to blood draw (+ steroids) (n = 6) or those who had not (- steroids) (n = 8). Results are displayed as box and whisker plots with each dot representing an individual donor. p value determined by unpaired students t-test. Correlation analysis of total CNS-EEV concentrations for active RRMS patients versus EDSS score (n = 16) (B) or days between MRI and blood draw (n = 11) (C). D Correlation analysis of total CNS-EEV concentrations for active RRMS patients CNS-EEV31, CNS-EEV105, and CNS-EEV144 concentrations. *** p ≤ 0.001, *** p ≤ 0.0001 determined by Pearson’s r analysis. Pearson’s correlation coefficient (r) and r² values are indicated in graphs for significant correlations. Paired t test plots for comparison of CNS-EEV31 versus CNS-EEV105 (E), CNS-EEV31 versus CNS-EEV144 (F), and CNS-EEV105 versus CNS-EEV144 (G) for individual active RRMS patients. Each pair represents an individual active RRMS patient. * p ≤ 0.05, ** p ≤ 0.01