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. 2022 Feb 7;20:64. doi: 10.1186/s12916-021-02197-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Association between individual methylation DMRs and prognosis in the EHSH cohort. A Diagram of the workflow of developing the 12-DMR model. B, C Association between the LASSO-based risk and overall survival in the training set (B) and the validation set (C). D Heatmap and table illustrating the methylation data and features of the 12 DMRs involved in the LASSO model. E, F Kaplan-Meier curves illustrating the OS data of 80 BTC patients of the subgroups classified by LASSO-based risk and TNM stage (E) and the subgroups classified by LASSO-based risk and anatomic location (F). BTC, biliary tract cancer; DMR, differentially methylated region; LASSO, least absolute shrinkage and selection operator