Table 3.
Hazard ratio in univariate analysis and multivariate analysis
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | P | Hazard ratio | 95% CI | P | |
| Age | 1.02 | 1.01–1.04 | 0.015 | 1.04 | 1.02–1.06 | 0.001 |
| Comorbidity | 2.01 | 1.24–3.23 | 0.005 | 2.05 | 1.21–3.49 | 0.008 |
| DNTM | 1.81 | 1.12–2.90 | 0.015 | 2.08 | 1.17–3.68 | 0.012 |
| HIV viral load | 1.25 | 1.07–1.46 | 0.006 | 1.32 | 1.12–1.55 | 0.001 |
| Linezolid | 3.64 | 1.85–7.15 | 0.001 | 4.71 | 2.25–9.83 | 0.001 |
| Sex | 1.59 | 0.50–5.04 | 0.435 | – | – | 0.697 |
| Smoking | 0.86 | 0.31–2.35 | 0.764 | – | – | 0.411 |
| Alcoholism | 1.30 | 0.32–5.29 | 0.719 | – | – | 0.592 |
| Opportunistic infection | 0.98 | 0.60–1.61 | 0.946 | – | – | 0.411 |
| CD4+ T cell count | 1.00 | 1.00–1.00a | 0.243 | – | – | 0.795 |
| ART before NTM treatment | 0.53 | 0.32–0.89 | 0.015 | – | – | 0.221 |
| Time to culture positivity | 0.98 | 0.96–1.01 | 0.125 | – | – | 0.232 |
Sex, age, smoking, alcoholism, comorbidity, opportunistic infection, CD4+ T cell count, HIV viral load, ART before NTM treatment, linezolid, DNTM and time to culture positivity were added to the model using stepwise procedures
–: blank (In the multivariate analysis, SPSS 25.0 did not show 95% CI and hazard ratio for variables that were not statistically significant); a: 95% CI for hazard ratio of CD4+ T cell count: 0.996–1.001
HIV human immunodeficiency virus, NTM nontuberculous mycobacteria, DNTM disseminated nontuberculous mycobacteria, ART antiretroviral therapy