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Semi-quantitative scoring system of p16INK4a immunostaining
| Percentage of immunoreactive cells | Staining pattern | p16INK4a expression assessment | Reference |
|---|---|---|---|
| 0–5% | Negative | Negative | Gabrielli Fregonesi et al. [46] |
| 6–10% | Sporadic | Positive (low expression) | |
| 11–30% | Focal | Positive (moderate expression) | |
| More than 30% | Diffuse | Positive (high expression) |
