Table 7.
The comparison of clinicopathological characteristics between p16INK4a/Ki-67/ p53 positive and negative RCC patients (n = 118)
| Variable | p53 Pos N (%) |
p53 Neg N (%) |
p value | P16 Pos N (%) |
P16 Neg N (%) |
p value | Ki-67 Pos N (%) |
Ki-67 Neg N (%) |
p value | High cyto- NF-κB N (%) |
Low cyto- NF-κB N (%) |
p value | High nuclear NF-κB N (%) |
Low nuclear NF-κB N (%) |
p value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | 11 (9.3) | 107 (90.7) | 24 (20.3) | 94 (79.7) | 24 (20.3) | 94 (79.7) | 98 (83.0) | 20 (16.9) | 70 (59.3) | 48 (40.7) | |||||
| Gender | |||||||||||||||
| Male | 7 (63.6) | 61 (57) | 0.757 | 17 (70.8) | 51 (54.3) | 0.169 | 18 (75) | 50 (53.2) | 0.065 | 56 (57.1) | 12 (60.0) | > 0.999 | 38 (54.3) | 30 (62.5) | 0.449 |
| Female | 4 (36.4) | 46 (43) | 7 (29.1) | 43 (45.7) | 6 (25) | 44 (46.8) | 42 (42.9) | 8 (40.0) | 32 (45.7) | 18 (37.5) | |||||
| Age | |||||||||||||||
| ≥ 54 | 6 (54.5) | 57 (53.3) | > 0.999 | 10 (41.6) | 53 (56.4) | 0.253 | 15 (62.5) | 48 (51.1) | 0.364 | 52 (53.1) | 11 (55) | > 0.999 | 42 (60) | 21 (43.7) | 0.094 |
| ˂ 54 | 5 (45.5) | 50 (46.7) | 14 (58.3) | 41 (43.6) | 9 (37.5) | 46 (48.9) | 46 (46.9) | 9 (45) | 28 (40) | 27 (56.2) | |||||
| Tumor location | |||||||||||||||
| Right | 7 (63.6) | 58 (54.2) | 0.752 | 14 (58.3) | 51 (54.3) | 0.819 | 11 (45.8) | 54 (57.4) | 0.361 | 56 (57.1) | 9 (45.0) | 0.336 | 36 (51.4) | 29 (60.4) | 0.353 |
| Left | 4 (36.4) | 49 (45.8) | 10 (41.6) | 43 (45.7) | 13 (54.2) | 40 (42.6) | 42 (42.9) | 11 (55.0) | 34 (48.6) | 19 (39.6) | |||||
| Tumor grade | |||||||||||||||
| G1 | 3 (27.2) | 50 (46.7) | 0.006 | 9 (37.5) | 44 (46.8) | 0.280 | 3 (12.5) | 50 (53.2) | < 0.0001 | 36 (36.7) | 17 (85.0) | 0.003 | 30 (42.9) | 23 (47.9) | 0.485 |
| G2 | 2 (18.1) | 40 (37.3) | 8 (33.3) | 34 (36.1) | 7 (29.2) | 35 (37.2) | 39 (39.8) | 3 (15.0) | 23 (32.8) | 19 (39.6) | |||||
| G3 | 6 (54.5) | 14 (13.1) | 7 (29.1) | 13 (13.8) | 13 (54.2) | 7 (7.4) | 20 (20.4) | 0 | 15 (21.4) | 5 (10.4) | |||||
| G4 | 0 | 3 (2.8) | 0 | 3 (3.2) | 1 (4.1) | 2 (2.1) | 3 (3.1) | 0 | 2 (2.9) | 1 (2.1) | |||||
| G1 + G2 | 5 (45.5) | 90 (84.1) | 0.007 | 17 (70.8) | 78 (82.9) | 0.246 | 10 (41.7) | 85 (90.4) | < 0.0001 | 75 (76.5) | 20 (100) | 0.012 | 53 (75.7) | 42 (87.5) | 0.156 |
| G3 + G4 | 6 (54.5) | 17 (15.9) | 7 (29.1) | 16 (17.0) | 14 (58.3) | 9 (9.6) | 23 (23.50 | 0 | 17 (24.3) | 6 (12.5) | |||||
| pT category | |||||||||||||||
| pT1 | 6 (54.5) | 49 (45.8) | 0.014 | 11 (45.8) | 44 (46.8) | 0.209 | 8 (33.3) | 47 (50) | 0.0002 | 42 (42.8) | 13 (65) | 0.254 | 31 (44.3) | 24 (50) | 0.364 |
| pT2 | 3 (27.2) | 40 (37.3) | 6 (25.0) | 37 (39.4) | 5 (20.8) | 38 (40.4) | 37 (37.7) | 6 (30) | 29 (41.4) | 14 (29.2) | |||||
| pT3 | 1 (9.1) | 18 (16.8) | 7 (29.1) | 12 (12.7) | 10 (41.7) | 9 (9.6) | 18 (18.4) | 1 (5) | 10 (14.3) | 9 (18.7) | |||||
| pT4 | 1 (9.1) | 0 | 0 | 1 (1.1) | 1 (4.2) | 0 | 1 (1.0) | 0 | 0 | 1 (2.1) | |||||
| pT1 + pT2 | 9 (81.9) | 89 (83.2) | > 0.999 | 17 (70.8) | 81 (86.1) | 0.122 | 13 (54.2) | 85 (90.4) | 0.0001 | 79 (80.6) | 19 (95) | 0.190 | 60 (85.7) | 38 (79.2) | 0.351 |
| pT3 + pT4 | 2 (18.1) | 18 (16.8) | 7 (29.1) | 13 (13.8) | 11 (45.8) | 9 (9.6) | 19 (19.4) | 1 (5) | 10 (14.3) | 10 (20.8) | |||||
| Histologic types | |||||||||||||||
| Conventional | 3 (27.3) | 70 (65.4) | 0.020 a | 12 (50) | 61 (64.9) | 0.239 | 12 (50) | 61 (64.9) | 0.239 a | 61 (62.2) | 12 (60) | 0.850 | 41 (58.6) | 32 (66.6) | 0.373 |
| Nonconventional | 8 (72.7) | 37 (34.6) | 12 (50) | 33 (35.1) | 12 (50) | 33 (35.1) | 37 (37.7) | 8 (40) | 29 (41.4) | 16 (33.3) | |||||
| Papillary | 6 (54.5) | 20 (18.7) | 9 (37.5) | 17 (18.1) | 8 (33.3) | 18 (19.1) | 23 (23.4) | 3 (15) | 20 (28.6) | 6 (12.5) | |||||
| Chromophobe | 1 (9.1) | 13 (12.1) | 1 (4.1) | 13 (13.8) | 0 | 14 (14.9) | 9 (9.2) | 5 (25) | 5 (7.1) | 9 (18.7) | |||||
| Collecting duct | 0 | 1 (0.9) | 0 | 1 (1.1) | 1 (4.2) | 0 | 1 (1.0) | 0 | 1 (1.4) | 0 | |||||
| Unclassified | 1 (9.1) | 3 (2.8) | 2 (8.3) | 2 (2.1) | 3 (12.5) | 1 (1.1) | 4 (4.1) | 0 | 3 (4.3) | 1 (2.1) | |||||
| EBV | |||||||||||||||
| Positive | 5 (45.4) | 28 (26.2) | 0.287 | 8 (33.3) | 25 (26.6) | 0.611 | 8 (33.3) | 25 (26.6) | 0.611 | 31 (31.6) | 2 (10) | 0.058 | 29 (41.4) | 4 (8.3) | < 0.0001 |
| Negative | 6 (54.5) | 79 (73.8) | 16 (66.6) | 69 (73.4) | 16 (66.6) | 69 (73.6) | 67 (68.4) | 18 (90) | 41 (58.6) | 44 (91.7) | |||||
Pos positive, Neg negative, Cyto cytoplasmic, P16 p16INK4a, pT primary tumor