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. 2022 Feb 8;20:55. doi: 10.1186/s12916-022-02248-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — NOD1 and NOD2 promoted migration and invasion of CSCC cells. A Representative images showing wound closure of control and NOD1/2-overexpressing Siha and CasKi cells at 24 h after scratching. The percentage of wound healing is shown on the right. Data represent triplicates of one representative experiment. B, C The representative images indicating migration (panel B) (Siha, CasKi and C33a) and invasion (panel C) (Siha and CasKi) ability of NOD1/NOD2-overexpressing cell lines by transwell assay (reproducible in three independent experiments in triplicate wells). D Representative migration and invasion images of the primary CSCC cells by transwell members (The cells were pretreated with 10 ng/mL Tri-DAP or MDP at 24 h) (three independent experiments with three primary CSCC cells, triplicate wells; magnification × 100). E Number of lung metastatic nodules (The yellow arrows indicate representatively metastatic nodes in fresh lung; the red arrows indicate the nodes in fixed lung) in mice injected with Siha/LV-Ctrl, Siha/LV-NOD1, and Siha/LV-NOD2 cells (mouse harboring Siha/LV-Ctrl: n = 6, mouse harboring Siha/LV-NOD1: n = 6, mouse harboring Siha/LV-NOD2: n = 6). F Kaplan-Meier curves showing OS of the above tumor-bearing groups (n = 10 for each group). All data are presented as mean ± SD. *P < 0.05; ** P < 0.01; *** P < 0.001