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. 2022 Feb 8;20:55. doi: 10.1186/s12916-022-02248-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Reparixin inhibited growth of NOD1^high and NOD2^high CSCC tumors in vivo. A Volume of Siha/LV-NOD1 and Siha/LV-NOD2 tumors in the untreated (n = 5), Reparixin (n = 10), and EVP4593 (n = 10) groups. B Tumor weight in the Reparixin (n = 10), EVP4593 (n = 10), and PBS (n = 5) groups. C OS Kaplan-Meier curves of mice in the above groups. D Representative fluorescence images showing metastasis of GFP+ Siha/LV-NOD1 or Siha/LV-NOD2 cells in the indicated groups (mouse harboring GFP+ Siha/LV-NOD1: Group treated by PBS: n = 9; group treated by Reparixin: n = 8; group treated by EVP4593: n = 6. mouse harboring GFP+ Siha/LV-NOD2: Group treated by PBS: n = 9; group treated by Reparixin: n = 8; group treated by EVP4593: n = 6). Quantification of GFP intensity is shown on the right. E Survival curves of the above tumor-bearing mice treated with PBS, Reparixin, or EVP4593. The results are presented as mean ± SD. ***P < 0.001; **P < 0.01; * P < 0.05